Assay Detail
Functional
CHEMBL1104121
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Antiviral activity against HIV1 Ba-L infected in PBMCs assessed as reverse transcriptase activity after 7 days by MTS assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Multivalent binding oligomers inhibit HIV Tat-TAR interaction critical for viral replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.26 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1075830 | — | — | 1 | 5.70 |
| CHEMBL1075825 | — | — | 1 | 5.40 |
| CHEMBL1075815 | — | — | 1 | 5.30 |
| CHEMBL1075821 | — | — | 1 | 5.16 |
| CHEMBL1075829 | — | — | 1 | 5.05 |
| CHEMBL1075828 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1075830 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1075825 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1075815 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1075821 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1075829 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1075828 | — | IC50 | = | 11000.0 | nM | 4.96 |