Assay Detail
Functional
CHEMBL1104127
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Antiviral activity against HIV1 BR/93/020 infected in PBMCs assessed as reverse transcriptase activity after 7 days by XTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Multivalent binding oligomers inhibit HIV Tat-TAR interaction critical for viral replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.25 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1075830 | — | — | 1 | 5.33 |
| CHEMBL1075825 | — | — | 1 | 5.29 |
| CHEMBL1075815 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1075830 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1075825 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL1075815 | — | IC50 | = | 7500.0 | nM | 5.12 |