Assay Detail
Binding
CHEMBL1104158
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Inhibition of GSK3-beta assessed as decrease in NADH absorbance at 340 nm in the presence of
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
4-(Benzimidazol-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: potent and selective p70S6 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 6.11 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1079295 | — | — | 1 | 6.68 |
| CHEMBL1078929 | — | — | 1 | 6.62 |
| CHEMBL1078930 | — | — | 1 | 6.54 |
| CHEMBL1079294 | — | — | 1 | 6.42 |
| CHEMBL1079040 | — | — | 1 | 6.41 |
| CHEMBL1080072 | — | — | 1 | 6.34 |
| CHEMBL1078426 | — | — | 1 | 6.21 |
| CHEMBL365286 | GW549034X | — | 1 | 6.16 |
| CHEMBL1077670 | — | — | 1 | 6.16 |
| CHEMBL1078820 | — | — | 1 | 6.16 |
| CHEMBL1078538 | — | — | 1 | 6.00 |
| CHEMBL1079032 | — | — | 1 | 5.96 |
| CHEMBL1079208 | — | — | 1 | 5.82 |
| CHEMBL1080071 | — | — | 1 | 5.68 |
| CHEMBL1079135 | — | — | 1 | 5.50 |
| CHEMBL1078717 | — | — | 1 | 5.14 |
| CHEMBL1078427 | — | — | 1 | - |
| CHEMBL1078537 | — | — | 1 | - |
| CHEMBL1078539 | — | — | 1 | - |
| CHEMBL1078155 | — | — | 1 | - |
| CHEMBL1078245 | — | — | 1 | - |
| CHEMBL1079293 | — | — | 1 | - |
| CHEMBL1080073 | — | — | 1 | - |
| CHEMBL1080245 | — | — | 1 | - |
| CHEMBL1080970 | — | — | 1 | - |
| CHEMBL1079243 | — | — | 1 | - |
| CHEMBL1082061 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1079295 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL1078929 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL1078930 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL1079294 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL1079040 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL1080072 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL1078426 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL365286 | GW549034X | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL1077670 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL1078820 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL1078538 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL1079032 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL1079208 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL1080071 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL1079135 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL1078717 | — | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL1078427 | — | Ki | > | 3300.0 | nM | - |
| CHEMBL1078537 | — | Ki | > | 2500.0 | nM | - |
| CHEMBL1078539 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL1078155 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL1078245 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL1079293 | — | Ki | > | 3300.0 | nM | - |
| CHEMBL1080073 | — | Ki | > | 3300.0 | nM | - |
| CHEMBL1080245 | — | Ki | > | 3300.0 | nM | - |
| CHEMBL1080970 | — | Ki | > | 3300.0 | nM | - |
| CHEMBL1079243 | — | Ki | > | 3300.0 | nM | - |
| CHEMBL1082061 | — | Ki | > | 3300.0 | nM | - |