Compound Detail
CHEMBL365286
GW549034X Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL365286 |
| Name | GW549034X |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HCRQPXYLXXLKPT-UHFFFAOYSA-N |
5
Targets
5
Activities
2
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
229.2
MW (Da)
1.69
ALogP
6
HBA
1
HBD
82.8
PSA (Ų)
0.72
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 7.3
IC50 1 meas. best 6.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ribosomal protein S6 kinase beta-1 CHEMBL4501 | Ki | 7.3 | 7.3 | 50.0 | 1 |
| Ribosomal protein S6 kinase alpha-5 CHEMBL4237 | IC50 | 6.85 | 6.85 | 140.0 | 1 |
| Rho-associated protein kinase 1 CHEMBL3231 | Ki | 6.48 | 6.48 | 330.0 | 1 |
| Glycogen synthase kinase-3 beta CHEMBL262 | Ki | 6.16 | 6.16 | 700.0 | 1 |
| cAMP-dependent protein kinase catalytic subunit alpha CHEMBL4101 | Ki | 6.02 | 6.02 | 960.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ribosomal protein S6 kinase beta-1 | Ki | = | 50.0 | nM | 7.3 | Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the pr... | 19632115 |
| Ribosomal protein S6 kinase alpha-5 | IC50 | = | 140.0 | nM | 6.85 | Inhibitory concentration exhibited towards MSK-1 | 15950465 |
| Rho-associated protein kinase 1 | Ki | = | 330.0 | nM | 6.48 | Inhibition of ROCK1 assessed as decrease in NADH absorbance at 340 nm in the pre... | 19632115 |
| Glycogen synthase kinase-3 beta | Ki | = | 700.0 | nM | 6.16 | Inhibition of GSK3-beta assessed as decrease in NADH absorbance at 340 nm in the... | 19632115 |
| cAMP-dependent protein kinase catalytic subunit alpha | Ki | = | 960.0 | nM | 6.02 | Inhibition of PKAalpha assessed as decrease in NADH absorbance at 340 nm in the ... | 19632115 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase ABL1 | 14 |
| - | 10.6019/CHEMBL1961873 | Epidermal growth factor receptor | 10 |
| - | 10.6019/CHEMBL1961873 | Mast/stem cell growth factor receptor Kit | 8 |
| - | 10.6019/CHEMBL1961873 | Platelet-derived growth factor receptor alpha | 8 |
| - | 10.6019/CHEMBL1961873 | Proto-oncogene tyrosine-protein kinase receptor Ret | 6 |
| - | 10.6019/CHEMBL1961873 | Receptor-type tyrosine-protein kinase FLT3 | 4 |
| - | 10.6019/CHEMBL1961873 | Cyclin-dependent kinase 2 | 4 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase B-raf | 4 |
| - | 10.6019/CHEMBL1961873 | Protein kinase C beta type | 4 |
| - | 10.6019/CHEMBL1961873 | Leucine-rich repeat serine/threonine-protein kinase 2 | 4 |
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase Lyn | 4 |
| - | 10.6019/CHEMBL5303304 | U2OS | 3 |
| - | 10.6019/CHEMBL1961873 | ALK tyrosine kinase receptor | 2 |
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase ABL2 | 2 |
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase receptor UFO | 2 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase PAK 6 | 2 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase PAK 1 | 2 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase 26 | 2 |
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase CSK | 2 |
| - | 10.6019/CHEMBL1961873 | Ephrin type-A receptor 4 | 2 |
Data from ChEMBL 36 via Core Engine