Assay Detail
Binding
CHEMBL1104159
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ROCK1 assessed as decrease in NADH absorbance at 340 nm in the presence of
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
4-(Benzimidazol-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: potent and selective p70S6 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 6.20 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1080071 | — | — | 1 | 7.07 |
| CHEMBL1079294 | — | — | 1 | 6.75 |
| CHEMBL365286 | GW549034X | — | 1 | 6.48 |
| CHEMBL1079295 | — | — | 1 | 6.47 |
| CHEMBL1078930 | — | — | 1 | 6.44 |
| CHEMBL1079293 | — | — | 1 | 6.35 |
| CHEMBL1078426 | — | — | 1 | 6.23 |
| CHEMBL1078820 | — | — | 1 | 6.18 |
| CHEMBL1078929 | — | — | 1 | 6.14 |
| CHEMBL1078427 | — | — | 1 | 6.09 |
| CHEMBL1079040 | — | — | 1 | 6.03 |
| CHEMBL1080072 | — | — | 1 | 6.03 |
| CHEMBL1078539 | — | — | 1 | 5.89 |
| CHEMBL1079208 | — | — | 1 | 5.72 |
| CHEMBL1078245 | — | — | 1 | 5.68 |
| CHEMBL1079032 | — | — | 1 | 5.66 |
| CHEMBL1082061 | — | — | 1 | - |
| CHEMBL1078717 | — | — | 1 | - |
| CHEMBL1077670 | — | — | 1 | - |
| CHEMBL1079243 | — | — | 1 | - |
| CHEMBL1080970 | — | — | 1 | - |
| CHEMBL1079135 | — | — | 1 | - |
| CHEMBL1080245 | — | — | 1 | - |
| CHEMBL1080073 | — | — | 1 | - |
| CHEMBL1078155 | — | — | 1 | - |
| CHEMBL1078538 | — | — | 1 | - |
| CHEMBL1078537 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1080071 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL1079294 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL365286 | GW549034X | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL1079295 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL1078930 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL1079293 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL1078426 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL1078820 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL1078929 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL1078427 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL1079040 | — | Ki | = | 930.0 | nM | 6.03 |
| CHEMBL1080072 | — | Ki | = | 940.0 | nM | 6.03 |
| CHEMBL1078539 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL1079208 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL1078245 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL1079032 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL1082061 | — | Ki | > | 3300.0 | nM | - |
| CHEMBL1078717 | — | Ki | > | 3300.0 | nM | - |
| CHEMBL1077670 | — | Ki | > | 3300.0 | nM | - |
| CHEMBL1079243 | — | Ki | > | 3300.0 | nM | - |
| CHEMBL1080970 | — | Ki | > | 3300.0 | nM | - |
| CHEMBL1079135 | — | Ki | > | 3300.0 | nM | - |
| CHEMBL1080245 | — | Ki | > | 3300.0 | nM | - |
| CHEMBL1080073 | — | Ki | > | 3300.0 | nM | - |
| CHEMBL1078155 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL1078538 | — | Ki | > | 2500.0 | nM | - |
| CHEMBL1078537 | — | Ki | > | 2500.0 | nM | - |