Assay Detail
Binding
CHEMBL1104157
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Inhibition of PKAalpha assessed as decrease in NADH absorbance at 340 nm in the presence of
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
cAMP-dependent protein kinase catalytic subunit alpha (CHEMBL4101) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-(Benzimidazol-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: potent and selective p70S6 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 6.05 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1080071 | — | — | 1 | 7.47 |
| CHEMBL1078930 | — | — | 1 | 6.42 |
| CHEMBL1079294 | — | — | 1 | 6.27 |
| CHEMBL1078929 | — | — | 1 | 6.22 |
| CHEMBL1079295 | — | — | 1 | 6.14 |
| CHEMBL365286 | GW549034X | — | 1 | 6.02 |
| CHEMBL1079040 | — | — | 1 | 5.96 |
| CHEMBL1079243 | — | — | 1 | 5.92 |
| CHEMBL1078426 | — | — | 1 | 5.89 |
| CHEMBL1078820 | — | — | 1 | 5.85 |
| CHEMBL1080970 | — | — | 1 | 5.82 |
| CHEMBL1080072 | — | — | 1 | 5.60 |
| CHEMBL1079135 | — | — | 1 | 5.58 |
| CHEMBL1079032 | — | — | 1 | 5.55 |
| CHEMBL1077670 | — | — | 1 | - |
| CHEMBL1078717 | — | — | 1 | - |
| CHEMBL1080245 | — | — | 1 | - |
| CHEMBL1080073 | — | — | 1 | - |
| CHEMBL1082061 | — | — | 1 | - |
| CHEMBL1078245 | — | — | 1 | - |
| CHEMBL1078155 | — | — | 1 | - |
| CHEMBL1078539 | — | — | 1 | - |
| CHEMBL1078538 | — | — | 1 | - |
| CHEMBL1078537 | — | — | 1 | - |
| CHEMBL1078427 | — | — | 1 | - |
| CHEMBL1079293 | — | — | 1 | - |
| CHEMBL1079208 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1080071 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL1078930 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL1079294 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL1078929 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL1079295 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL365286 | GW549034X | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL1079040 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL1079243 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL1078426 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL1078820 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL1080970 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL1080072 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL1079135 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL1079032 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL1077670 | — | Ki | > | 3300.0 | nM | - |
| CHEMBL1078717 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL1080245 | — | Ki | > | 3300.0 | nM | - |
| CHEMBL1080073 | — | Ki | > | 3300.0 | nM | - |
| CHEMBL1082061 | — | Ki | > | 3300.0 | nM | - |
| CHEMBL1078245 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL1078155 | — | Ki | - | — | - | |
| CHEMBL1078539 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL1078538 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL1078537 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL1078427 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL1079293 | — | Ki | > | 3300.0 | nM | - |
| CHEMBL1079208 | — | Ki | > | 3300.0 | nM | - |