Assay Detail
Binding
CHEMBL828472
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Inhibitory concentration exhibited towards MSK-1
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
(1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: a novel class of potent MSK-1-inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.93 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185962 | — | — | 1 | 8.74 |
| CHEMBL189231 | — | — | 1 | 8.52 |
| CHEMBL189657 | — | — | 1 | 8.52 |
| CHEMBL188433 | — | — | 1 | 7.96 |
| CHEMBL188457 | — | — | 1 | 7.89 |
| CHEMBL363054 | — | — | 1 | 7.77 |
| CHEMBL189094 | — | — | 1 | 7.77 |
| CHEMBL189299 | — | — | 1 | 7.70 |
| CHEMBL187339 | — | — | 1 | 7.42 |
| CHEMBL361678 | — | — | 1 | 7.26 |
| CHEMBL191104 | — | — | 1 | 6.97 |
| CHEMBL188048 | — | — | 1 | 6.90 |
| CHEMBL365286 | GW549034X | — | 1 | 6.85 |
| CHEMBL365902 | — | — | 1 | 6.59 |
| CHEMBL185731 | — | — | 1 | 6.01 |
| CHEMBL362712 | — | — | 1 | 5.92 |
| CHEMBL189120 | — | — | 1 | 5.82 |
| CHEMBL185710 | — | — | 1 | 5.81 |
| CHEMBL361690 | — | — | 1 | 5.71 |
| CHEMBL426800 | GW785404X | — | 1 | 5.67 |
| CHEMBL364990 | — | — | 1 | 5.36 |
| CHEMBL362494 | — | — | 1 | 5.29 |
| CHEMBL188342 | — | — | 1 | - |
| CHEMBL363546 | — | — | 1 | - |
| CHEMBL188543 | — | — | 1 | - |
| CHEMBL188571 | — | — | 1 | - |
| CHEMBL188908 | — | — | 1 | - |
| CHEMBL372432 | — | — | 1 | - |
| CHEMBL361257 | — | — | 1 | - |
| CHEMBL185689 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185962 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL189231 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL189657 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL188433 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL188457 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL363054 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL189094 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL189299 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL187339 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL361678 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL191104 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL188048 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL365286 | GW549034X | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL365902 | — | IC50 | = | 258.0 | nM | 6.59 |
| CHEMBL185731 | — | IC50 | = | 974.0 | nM | 6.01 |
| CHEMBL362712 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL189120 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL185710 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL361690 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL426800 | GW785404X | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL364990 | — | IC50 | = | 4390.0 | nM | 5.36 |
| CHEMBL362494 | — | IC50 | = | 5097.0 | nM | 5.29 |
| CHEMBL188342 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL363546 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL188543 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL188571 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL188908 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL372432 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL361257 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL185689 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL415769 | — | IC50 | > | 10000.0 | nM | - |