Assay Detail
Binding
CHEMBL1104194
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Inhibition of CETP assessed as cholesterol ester transfer after 4 hrs by microemulsion based fluorescence assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel tetrahydrochinoline derived CETP inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.68 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1081450 | — | — | 1 | 7.77 |
| CHEMBL479527 | TORCETRAPIB | 3.0 | 1 | 7.75 |
| CHEMBL1081802 | — | — | 1 | 7.66 |
| CHEMBL1086624 | — | — | 1 | 7.62 |
| CHEMBL1081288 | — | — | 1 | 7.60 |
| CHEMBL1081287 | — | — | 1 | 7.52 |
| CHEMBL1086623 | — | — | 1 | 7.51 |
| CHEMBL1086637 | — | — | 1 | 7.48 |
| CHEMBL1081307 | — | — | 1 | 7.41 |
| CHEMBL1080543 | — | — | 1 | 7.26 |
| CHEMBL1080866 | — | — | 1 | 7.22 |
| CHEMBL1087412 | — | — | 1 | 7.16 |
| CHEMBL1087413 | — | — | 1 | 7.16 |
| CHEMBL1080751 | — | — | 1 | 7.16 |
| CHEMBL1080749 | — | — | 1 | 7.10 |
| CHEMBL1087411 | — | — | 1 | 7.05 |
| CHEMBL1081607 | — | — | 1 | 7.00 |
| CHEMBL1080750 | — | — | 1 | 7.00 |
| CHEMBL1087784 | — | — | 1 | 6.52 |
| CHEMBL1076557 | — | — | 1 | 6.30 |
| CHEMBL1087783 | — | — | 1 | 6.22 |
| CHEMBL1088039 | — | — | 1 | 6.22 |
| CHEMBL1087782 | — | — | 1 | 5.70 |
| CHEMBL1080709 | — | — | 1 | 5.70 |
| CHEMBL1080710 | — | — | 1 | 5.52 |
| CHEMBL1087154 | — | — | 1 | 5.52 |
| CHEMBL1081083 | — | — | 1 | 5.40 |
| CHEMBL1086625 | — | — | 1 | 5.35 |
| CHEMBL1076558 | — | — | 1 | 4.82 |
| CHEMBL1080385 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1081450 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL479527 | TORCETRAPIB | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1081802 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1086624 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1081288 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1081287 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1086623 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1086637 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1081307 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1080543 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1080866 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1087412 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1087413 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1080751 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1080749 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1087411 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1081607 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1080750 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1087784 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1076557 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1087783 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1088039 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1087782 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1080709 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1080710 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1087154 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1081083 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1086625 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1076558 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1080385 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1080732 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1080731 | — | IC50 | > | 20000.0 | nM | - |