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Assay Detail

CHEMBL1104415

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity at 5HT1A receptor
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 1A (CHEMBL214)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

The development and validation of a novel virtual screening cascade protocol to identify potential serotonin 5-HT(7)R antagonists.
Kurczab R, Nowak M, Chilmonczyk Z, Sylte I, Bojarski AJ.
Bioorg Med Chem Lett (2010) 20 : 2465 -2468
PubMed 20346662 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 7.77 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1091933 1 8.10
CHEMBL1094908 1 7.44

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1091933 Ki = 8.0 nM 8.10
CHEMBL1094908 Ki = 36.0 nM 7.44