Assay Detail
Binding
CHEMBL1104418
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counter
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP3 subtype (CHEMBL4336) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of novel N-acylsulfonamide analogs as potent and selective EP3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 9.08 | 10.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1091742 | — | — | 1 | 10.19 |
| CHEMBL1091741 | — | — | 1 | 10.07 |
| CHEMBL1090937 | — | — | 1 | 9.92 |
| CHEMBL1091743 | — | — | 1 | 9.89 |
| CHEMBL1092432 | — | — | 1 | 9.80 |
| CHEMBL1093820 | — | — | 1 | 9.70 |
| CHEMBL1091740 | — | — | 1 | 9.66 |
| CHEMBL1092976 | — | — | 1 | 9.57 |
| CHEMBL1093819 | — | — | 1 | 9.46 |
| CHEMBL1091738 | — | — | 1 | 9.37 |
| CHEMBL1091739 | — | — | 1 | 9.35 |
| CHEMBL1092266 | — | — | 1 | 9.30 |
| CHEMBL1092431 | — | — | 1 | 9.29 |
| CHEMBL1091744 | — | — | 1 | 9.27 |
| CHEMBL1093842 | — | — | 1 | 9.24 |
| CHEMBL1093841 | — | — | 1 | 9.00 |
| CHEMBL1092097 | — | — | 1 | 8.92 |
| CHEMBL1093537 | — | — | 1 | 8.80 |
| CHEMBL1090938 | — | — | 1 | 8.09 |
| CHEMBL1092267 | — | — | 1 | 7.82 |
| CHEMBL605833 | — | — | 1 | 7.68 |
| CHEMBL1093911 | — | — | 1 | 7.66 |
| CHEMBL1091959 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1091742 | — | Ki | = | 0.065 | nM | 10.19 |
| CHEMBL1091741 | — | Ki | = | 0.086 | nM | 10.07 |
| CHEMBL1090937 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL1091743 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL1092432 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL1093820 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL1091740 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL1092976 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL1093819 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL1091738 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL1091739 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL1092266 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL1092431 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL1091744 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL1093842 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL1093841 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1092097 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL1093537 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL1090938 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL1092267 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL605833 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL1093911 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL1091959 | — | Ki | = | 140.0 | nM | 6.85 |