Assay Detail
Functional
CHEMBL1104419
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level after 1 hr by FDSS in presence of 1% bovine serum albumin
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Serum |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP3 subtype (CHEMBL4336) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of novel N-acylsulfonamide analogs as potent and selective EP3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.61 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1092432 | — | — | 1 | 9.40 |
| CHEMBL1091741 | — | — | 1 | 8.92 |
| CHEMBL1091743 | — | — | 1 | 8.85 |
| CHEMBL1090937 | — | — | 1 | 8.42 |
| CHEMBL1091740 | — | — | 1 | 8.26 |
| CHEMBL1091744 | — | — | 1 | 8.19 |
| CHEMBL1091739 | — | — | 1 | 8.11 |
| CHEMBL1091738 | — | — | 1 | 8.00 |
| CHEMBL1091742 | — | — | 1 | 7.75 |
| CHEMBL1092431 | — | — | 1 | 7.62 |
| CHEMBL1090938 | — | — | 1 | 7.62 |
| CHEMBL1092097 | — | — | 1 | 7.33 |
| CHEMBL1092976 | — | — | 1 | 7.29 |
| CHEMBL1093820 | — | — | 1 | 7.23 |
| CHEMBL1093842 | — | — | 1 | 7.06 |
| CHEMBL1093819 | — | — | 1 | 6.96 |
| CHEMBL1092266 | — | — | 1 | 6.85 |
| CHEMBL1093841 | — | — | 1 | 6.82 |
| CHEMBL1093537 | — | — | 1 | 6.72 |
| CHEMBL605833 | — | — | 1 | 6.24 |
| CHEMBL1092267 | — | — | 1 | 6.09 |
| CHEMBL1091959 | — | — | 1 | - |
| CHEMBL1093911 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1092432 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1091741 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1091743 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1090937 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL1091740 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL1091744 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL1091739 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL1091738 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1091742 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1092431 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1090938 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1092097 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL1092976 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL1093820 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL1093842 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL1093819 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1092266 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1093841 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1093537 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL605833 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL1092267 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL1091959 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1093911 | — | IC50 | > | 10000.0 | nM | - |