Assay Detail
Binding
CHEMBL1104422
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counter
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP4 subtype (CHEMBL2489) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of novel N-acylsulfonamide analogs as potent and selective EP3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.66 | 6.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1092432 | — | — | 1 | 6.15 |
| CHEMBL1091743 | — | — | 1 | 5.75 |
| CHEMBL1092431 | — | — | 1 | 5.64 |
| CHEMBL1091741 | — | — | 1 | 5.62 |
| CHEMBL1093820 | — | — | 1 | 5.60 |
| CHEMBL1090937 | — | — | 1 | 5.46 |
| CHEMBL1091744 | — | — | 1 | 5.43 |
| CHEMBL1092976 | — | — | 1 | - |
| CHEMBL1090938 | — | — | 1 | - |
| CHEMBL1092097 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1092432 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL1091743 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL1092431 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL1091741 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL1093820 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL1090937 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL1091744 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL1092976 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1090938 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1092097 | — | Ki | > | 10000.0 | nM | - |