Assay Detail
Functional
CHEMBL1104447
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Vasodilatory activity in Wistar rat endothelium-intact thoracic aortic strip assessed as inhibition of phenylephrine-induced contraction after 120 mins
14
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and preliminary pharmacological characterisation of a new class of nitrogen-containing bisphosphonates (N-BPs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 7 | - | - |
| EC50 | 7 | 5.26 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1093436 | — | — | 2 | 6.70 |
| CHEMBL1091027 | — | — | 2 | 6.64 |
| CHEMBL1088773 | — | — | 2 | 4.46 |
| CHEMBL1090497 | — | — | 2 | 4.35 |
| CHEMBL1093434 | — | — | 3 | 4.14 |
| CHEMBL997 | IBANDRONIC ACID | 4.0 | 1 | - |
| CHEMBL1091521 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1093436 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1091027 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1088773 | — | EC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL1090497 | — | EC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL1093434 | — | EC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL997 | IBANDRONIC ACID | Inhibition | - | % | - | |
| CHEMBL1093434 | — | Inhibition | - | % | - | |
| CHEMBL1093436 | — | Inhibition | - | % | - | |
| CHEMBL1091521 | — | Inhibition | - | % | - | |
| CHEMBL1091027 | — | Inhibition | - | % | - | |
| CHEMBL1090497 | — | Inhibition | - | % | - | |
| CHEMBL1088773 | — | Inhibition | - | % | - | |
| CHEMBL1093434 | — | EC50 | - | — | - | |
| CHEMBL1091521 | — | EC50 | = | 108000.0 | nM | - |