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Assay Detail

CHEMBL1104541

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against mouse NIH/3T3 cells assessed as viable cells after 72 hrs by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Mus musculus
Cell Type NIH3T3
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

Investigating the anti-proliferative activity of styrylazanaphthalenes and azanaphthalenediones.
Mrozek-Wilczkiewicz A, Kalinowski DS, Musiol R, Finster J, Szurko A, Serafin K, Knas M, Kamalapuram SK, Kovacevic Z, Jampilek J, Ratuszna A, Rzeszowska-Wolny J, Richardson DR, Polanski J.
Bioorg Med Chem (2010) 18 : 2664 -2671
PubMed 20303768 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.69 5.93

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1090672 1 5.93
CHEMBL47360 1 5.62
CHEMBL1089792 1 5.52
CHEMBL1091870 1 -
CHEMBL1092203 1 -
CHEMBL1092204 1 -
CHEMBL1092205 1 -
CHEMBL1092206 1 -
CHEMBL1091869 1 -
CHEMBL1091029 1 -
CHEMBL1089789 1 -
CHEMBL1089790 1 -
CHEMBL1089791 1 -
CHEMBL1093129 1 -
CHEMBL1093130 1 -
CHEMBL241908 1 -
CHEMBL1091028 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1090672 IC50 = 1170.0 nM 5.93
CHEMBL47360 IC50 = 2400.0 nM 5.62
CHEMBL1089792 IC50 = 3040.0 nM 5.52
CHEMBL1091870 IC50 - -
CHEMBL1092203 IC50 - -
CHEMBL1092204 IC50 - -
CHEMBL1092205 IC50 - -
CHEMBL1092206 IC50 - -
CHEMBL1091869 IC50 - -
CHEMBL1091029 IC50 - -
CHEMBL1089789 IC50 - -
CHEMBL1089790 IC50 - -
CHEMBL1089791 IC50 - -
CHEMBL1093129 IC50 - -
CHEMBL1093130 IC50 - -
CHEMBL241908 IC50 - -
CHEMBL1091028 IC50 - -