Assay Detail
Binding
CHEMBL1104830
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HCMV DNA polymerase infected in HFF cells
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human betaherpesvirus 5 |
| Cell Type | HFF |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Modifications of C-2 on the pyrroloquinoline template aimed at the development of potent herpesvirus antivirals with improved aqueous solubility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.16 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1096372 | — | — | 1 | 6.54 |
| CHEMBL1097364 | — | — | 1 | 6.46 |
| CHEMBL1094084 | — | — | 1 | 6.46 |
| CHEMBL1099316 | — | — | 1 | 6.41 |
| CHEMBL1099315 | — | — | 1 | 6.41 |
| CHEMBL1096403 | — | — | 1 | 6.37 |
| CHEMBL1095386 | — | — | 1 | 6.36 |
| CHEMBL1095087 | — | — | 1 | 6.35 |
| CHEMBL1097715 | — | — | 1 | 6.34 |
| CHEMBL29711 | APHIDICOLIN | — | 1 | 6.31 |
| CHEMBL1095387 | — | — | 1 | 6.29 |
| CHEMBL1097716 | — | — | 1 | 6.28 |
| CHEMBL1096390 | — | — | 1 | 6.26 |
| CHEMBL1096391 | — | — | 1 | 6.19 |
| CHEMBL1096402 | — | — | 1 | 6.14 |
| CHEMBL1094083 | — | — | 1 | 6.10 |
| CHEMBL1098655 | — | — | 1 | 6.10 |
| CHEMBL1095088 | — | — | 1 | 6.05 |
| CHEMBL1099067 | — | — | 1 | 5.96 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.89 |
| CHEMBL666 | FOSCARNET | 4.0 | 1 | 5.60 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | -1.0 | 1 | 4.66 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1096372 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1097364 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1094084 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1099316 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1099315 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1096403 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1095386 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL1095087 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1097715 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL29711 | APHIDICOLIN | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL1095387 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL1097716 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL1096390 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1096391 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL1096402 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL1094083 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1098655 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1095088 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1099067 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL182 | GANCICLOVIR | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL666 | FOSCARNET | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL184 | ACYCLOVIR | IC50 | > | 20000.0 | nM | - |