Assay Detail
Functional
CHEMBL1104834
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Antiviral activity against HSV1 KOS infected in african green monkey Vero cells assessed as reduction in plaque formation
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Modifications of C-2 on the pyrroloquinoline template aimed at the development of potent herpesvirus antivirals with improved aqueous solubility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.83 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1097364 | — | — | 1 | 6.10 |
| CHEMBL1095387 | — | — | 1 | 5.92 |
| CHEMBL1096390 | — | — | 1 | 5.77 |
| CHEMBL1095087 | — | — | 1 | 5.68 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.68 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1097364 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1095387 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1096390 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1095087 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL184 | ACYCLOVIR | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL182 | GANCICLOVIR | IC50 | - | — | - |