Assay Detail
Binding
CHEMBL1105079
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Activation of progesterone receptor in human T47D cells after 20 hrs by PRE-tagged luciferase reporter gene assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 9.49 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 10.00 |
| CHEMBL1087512 | LECANINDOLE B | — | 1 | 9.52 |
| CHEMBL1076438 | LECANINDOLE D | — | 1 | 8.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103 | PROGESTERONE | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL1087512 | LECANINDOLE B | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL1076438 | LECANINDOLE D | EC50 | = | 1.1 | nM | 8.96 |