Assay Detail
Binding
CHEMBL1105082
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Inhibition of nNOS in HEK293T cells assessed as nitrite formation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.92 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL446971 | — | — | 1 | 5.05 |
| CHEMBL1086858 | — | — | 1 | 5.00 |
| CHEMBL1086859 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL446971 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1086858 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1086859 | — | IC50 | = | 19000.0 | nM | 4.72 |