Assay Detail
Binding
CHEMBL1105216
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Inhibition of wild type EGFR by HTRF assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 4-anilinoquinolines as potent inhibitors of epidermal growth factor receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.59 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188762 | — | — | 1 | 10.00 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 9.70 |
| CHEMBL1089524 | — | — | 1 | 8.77 |
| CHEMBL1092382 | — | — | 1 | 7.80 |
| CHEMBL1092250 | — | — | 1 | 7.72 |
| CHEMBL1089203 | — | — | 1 | 7.52 |
| CHEMBL1090840 | — | — | 1 | - |
| CHEMBL304929 | — | — | 1 | - |
| CHEMBL1088901 | — | — | 1 | - |
| CHEMBL285063 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188762 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1089524 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL1092382 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1092250 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1089203 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1090840 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL304929 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL1088901 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL285063 | — | IC50 | < | 1.0 | nM | - |