Assay Detail
Functional
CHEMBL1105503
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at recombinant GluA1 receptor flop isoform expressed in Xenopus oocytes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | Oocyte |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.08 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL602962 | — | — | 1 | 6.57 |
| CHEMBL73698 | — | — | 1 | 4.85 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 4.66 |
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL602962 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL73698 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL275040 | KAINIC ACID | EC50 | = | 60000.0 | nM | 4.22 |