Assay Detail
Functional
CHEMBL1105804
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Upregulation of SREB1c mRNA level in human HuH7 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.15 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1097799 | — | — | 1 | 8.22 |
| CHEMBL1098403 | — | — | 1 | 8.10 |
| CHEMBL1096719 | — | — | 1 | 8.10 |
| CHEMBL62136 | T091317 | — | 1 | 7.44 |
| CHEMBL1094741 | — | — | 1 | 7.28 |
| CHEMBL1097140 | — | — | 1 | 6.88 |
| CHEMBL1098832 | — | — | 1 | 6.60 |
| CHEMBL1095714 | — | — | 1 | 6.36 |
| CHEMBL1098831 | — | — | 1 | 6.28 |
| CHEMBL1098402 | — | — | 1 | 6.24 |
| CHEMBL1097160 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1097799 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1098403 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1096719 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL62136 | T091317 | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1094741 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1097140 | — | EC50 | = | 132.0 | nM | 6.88 |
| CHEMBL1098832 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1095714 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL1098831 | — | EC50 | = | 521.0 | nM | 6.28 |
| CHEMBL1098402 | — | EC50 | = | 571.0 | nM | 6.24 |
| CHEMBL1097160 | — | EC50 | - | — | - |