Assay Detail
Functional
CHEMBL1105849
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Antitrypanosomal activity against pentamidine-sensitive Trypanosoma brucei brucei LAB 110 EATRO
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.45 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1081708 | — | — | 1 | 8.70 |
| CHEMBL1081887 | — | — | 1 | 8.70 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.70 |
| CHEMBL185175 | — | — | 1 | 8.52 |
| CHEMBL1081709 | — | — | 1 | 8.52 |
| CHEMBL1080776 | — | — | 1 | 8.10 |
| CHEMBL185063 | — | — | 1 | 8.05 |
| CHEMBL1079366 | — | — | 1 | 7.92 |
| CHEMBL1081522 | — | — | 1 | 7.39 |
| CHEMBL1081886 | — | — | 1 | 6.40 |
| CHEMBL1081521 | — | — | 1 | 5.55 |
| CHEMBL1080611 | — | — | 1 | 5.19 |
| CHEMBL1080610 | — | — | 1 | 5.05 |
| CHEMBL1078223 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1081708 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1081887 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL185175 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1081709 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1080776 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL185063 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1079366 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1081522 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1081886 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1081521 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1080611 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL1080610 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1078223 | — | IC50 | - | — | - |