Assay Detail
Functional
CHEMBL1105850
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Multidrug-resistant Trypanosoma brucei rhodesiense KETRI 243
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.40 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1081709 | — | — | 1 | 9.00 |
| CHEMBL185175 | — | — | 1 | 8.70 |
| CHEMBL1081708 | — | — | 1 | 8.70 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.70 |
| CHEMBL1081887 | — | — | 1 | 8.40 |
| CHEMBL1079366 | — | — | 1 | 8.15 |
| CHEMBL1080776 | — | — | 1 | 8.15 |
| CHEMBL1081522 | — | — | 1 | 7.68 |
| CHEMBL185063 | — | — | 1 | 7.02 |
| CHEMBL1081886 | — | — | 1 | 6.62 |
| CHEMBL1081521 | — | — | 1 | 5.96 |
| CHEMBL1078223 | — | — | 1 | 5.71 |
| CHEMBL1080610 | — | — | 1 | 5.66 |
| CHEMBL1080611 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1081709 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL185175 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1081708 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1081887 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1079366 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1080776 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1081522 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL185063 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL1081886 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1081521 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1078223 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL1080610 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL1080611 | — | IC50 | = | 7900.0 | nM | 5.10 |