Assay Detail
Functional
CHEMBL1105867
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Hepatoprotective activity in human HepG2 cells assessed as inhibition of H2O2- induced oxidative damage after 3 hrs by leucocrstal violet dye treated 1 hr before H2O2 challenge
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Sesquiterpene lactones from the root tubers of Lindera aggregata.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.18 | 4.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1079724 | HYDROXYLINDESTENOLIDE | — | 1 | 4.37 |
| CHEMBL1078133 | LINDERAGALACTONE E | — | 1 | 4.17 |
| CHEMBL1080239 | LINDERALACTONE | — | 1 | 4.01 |
| CHEMBL1079723 | LINDERANE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1079724 | HYDROXYLINDESTENOLIDE | EC50 | = | 42400.0 | nM | 4.37 |
| CHEMBL1078133 | LINDERAGALACTONE E | EC50 | = | 67500.0 | nM | 4.17 |
| CHEMBL1080239 | LINDERALACTONE | EC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL1079723 | LINDERANE | EC50 | = | 167000.0 | nM | - |