Assay Detail
Binding
CHEMBL1106056
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Inhibition of FLT3 by HTRF assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Indirubin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.84 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 8.30 |
| CHEMBL1095687 | — | — | 1 | 8.05 |
| CHEMBL1077291 | — | — | 1 | 7.82 |
| CHEMBL1097359 | — | — | 1 | 7.55 |
| CHEMBL126077 | INDIRUBIN-3-MONOXIME | — | 1 | 7.48 |
| CHEMBL369303 | — | — | 1 | 7.21 |
| CHEMBL511450 | — | — | 1 | 7.09 |
| CHEMBL604263 | — | — | 1 | 6.89 |
| CHEMBL111433 | — | — | 1 | 6.68 |
| CHEMBL367113 | — | — | 1 | 6.67 |
| CHEMBL368689 | — | — | 1 | 6.55 |
| CHEMBL594192 | — | — | 1 | 6.45 |
| CHEMBL337300 | — | — | 1 | 6.38 |
| CHEMBL1095374 | — | — | 1 | 6.02 |
| CHEMBL173445 | — | — | 1 | 5.33 |
| CHEMBL367345 | — | — | 1 | 5.00 |
| CHEMBL1085921 | — | — | 1 | - |
| CHEMBL174025 | — | — | 1 | - |
| CHEMBL1276127 | INDIRUBIN | 2.0 | 1 | - |
| CHEMBL1083839 | — | — | 1 | - |
| CHEMBL1095686 | — | — | 1 | - |
| CHEMBL1086983 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1095687 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1077291 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1097359 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL126077 | INDIRUBIN-3-MONOXIME | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL369303 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL511450 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL604263 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL111433 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL367113 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL368689 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL594192 | — | IC50 | = | 359.0 | nM | 6.45 |
| CHEMBL337300 | — | IC50 | = | 418.0 | nM | 6.38 |
| CHEMBL1095374 | — | IC50 | = | 952.0 | nM | 6.02 |
| CHEMBL173445 | — | IC50 | = | 4722.0 | nM | 5.33 |
| CHEMBL367345 | — | IC50 | = | 10070.0 | nM | 5.00 |
| CHEMBL1085921 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL174025 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1276127 | INDIRUBIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL1083839 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1095686 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1086983 | — | IC50 | > | 10000.0 | nM | - |