Compound Detail
CHEMBL368689
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Basic Information
| ChEMBL ID | CHEMBL368689 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AEXBCOHXODIJFZ-UHFFFAOYSA-M |
| Parent Compound | CHEMBL1207227 |
| Active Moiety | CHEMBL1207227 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
342.3
MW (Da)
2.44
ALogP
5
HBA
3
HBD
119.8
PSA (Ų)
0.62
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 6.55 | 6.55 | 280.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 280.0 | nM | 6.55 | Inhibition of FLT3 by HTRF assay | 20153646 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15993584 | 10.1016/j.bmcl.2005.05.105 | A549 | 1 |
| 15993584 | 10.1016/j.bmcl.2005.05.105 | Unchecked | 1 |
| 15993584 | 10.1016/j.bmcl.2005.05.105 | HT-1080 | 1 |
| 15993584 | 10.1016/j.bmcl.2005.05.105 | HL-60 | 1 |
| 20153646 | 10.1016/j.bmcl.2010.01.039 | Receptor-type tyrosine-protein kinase FLT3 | 1 |
| 20153646 | 10.1016/j.bmcl.2010.01.039 | NON-PROTEIN TARGET | 1 |
| 20153646 | 10.1016/j.bmcl.2010.01.039 | MV4-11 | 1 |
Data from ChEMBL 36 via Core Engine