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Assay Detail

CHEMBL1106116

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]DEX from human glucocorticoid receptor
38
Total Activities
19
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Glucocorticoid receptor (CHEMBL2034)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Virtual screening for the identification of novel nonsteroidal glucocorticoid modulators.
Onnis V, Kinsella GK, Carta G, Jagoe WN, Price T, Williams DC, Fayne D, Lloyd DG.
J Med Chem (2010) 53 : 3065 -3074
PubMed 20334371 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Activity 19 - -
Ki 19 7.88 10.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL78704 2 10.00
CHEMBL77779 2 10.00
CHEMBL78625 2 9.77
CHEMBL1276308 MIFEPRISTONE 4.0 2 9.62
CHEMBL384467 DEXAMETHASONE 4.0 2 8.96
CHEMBL1090477 2 8.70
CHEMBL131 PREDNISOLONE 4.0 2 8.62
CHEMBL7843 2 8.55
CHEMBL1089812 2 8.38
CHEMBL310180 2 8.22
CHEMBL1090805 2 8.16
CHEMBL1089811 2 7.75
CHEMBL1092578 2 7.52
CHEMBL1090801 2 7.29
CHEMBL53549 2 5.99
CHEMBL417729 2 5.75
CHEMBL1093625 2 5.61
CHEMBL1093779 2 5.49
CHEMBL1093140 2 5.39

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL78704 Ki = 0.1 nM 10.00
CHEMBL77779 Ki = 0.1 nM 10.00
CHEMBL78625 Ki = 0.17 nM 9.77
CHEMBL1276308 MIFEPRISTONE Ki = 0.24 nM 9.62
CHEMBL384467 DEXAMETHASONE Ki = 1.1 nM 8.96
CHEMBL1090477 Ki = 2.0 nM 8.70
CHEMBL131 PREDNISOLONE Ki = 2.4 nM 8.62
CHEMBL7843 Ki = 2.8 nM 8.55
CHEMBL1089812 Ki = 4.2 nM 8.38
CHEMBL310180 Ki = 6.0 nM 8.22
CHEMBL1090805 Ki = 6.9 nM 8.16
CHEMBL1089811 Ki = 18.0 nM 7.75
CHEMBL1092578 Ki = 30.0 nM 7.52
CHEMBL1090801 Ki = 51.0 nM 7.29
CHEMBL53549 Ki = 1036.0 nM 5.99
CHEMBL417729 Ki = 1766.0 nM 5.75
CHEMBL1093625 Ki = 2465.0 nM 5.61
CHEMBL1093779 Ki = 3210.0 nM 5.49
CHEMBL1093140 Ki = 4109.0 nM 5.39
CHEMBL1093779 Activity - -
CHEMBL1093625 Activity - -
CHEMBL417729 Activity - -
CHEMBL53549 Activity - -
CHEMBL7843 Activity - -
CHEMBL1092578 Activity - -
CHEMBL1089812 Activity - -
CHEMBL1089811 Activity - -
CHEMBL1093140 Activity - -
CHEMBL310180 Activity - -
CHEMBL1090805 Activity - -
CHEMBL131 PREDNISOLONE Activity - -
CHEMBL78704 Activity - -
CHEMBL1090801 Activity - -
CHEMBL1090477 Activity - -
CHEMBL1276308 MIFEPRISTONE Activity - -
CHEMBL78625 Activity - -
CHEMBL77779 Activity - -
CHEMBL384467 DEXAMETHASONE Activity - -