Assay Detail
Binding
CHEMBL1106166
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inhibition of Candida albicans recombinant Nce103 after 15 mins by stopped-flow CO2 hydration assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Candida albicans |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Carbonic anhydrase (CHEMBL5337) ↗| Type | SINGLE PROTEIN |
| Organism | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
Publication
Carbonic anhydrase inhibitors. The beta-carbonic anhydrases from the fungal pathogens Cryptococcus neoformans and Candida albicans are strongly inhibited by substituted-phenyl-1H-indole-5-sulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 7.30 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL501294 | — | — | 1 | 8.29 |
| CHEMBL1092054 | — | — | 1 | 8.12 |
| CHEMBL469126 | — | — | 1 | 7.72 |
| CHEMBL468294 | — | — | 1 | 7.68 |
| CHEMBL468094 | — | — | 1 | 7.62 |
| CHEMBL513854 | — | — | 1 | 7.54 |
| CHEMBL467258 | — | — | 1 | 7.51 |
| CHEMBL513835 | — | — | 1 | 7.48 |
| CHEMBL468946 | — | — | 1 | 7.39 |
| CHEMBL466832 | — | — | 1 | 7.38 |
| CHEMBL475972 | — | — | 1 | 7.37 |
| CHEMBL467897 | — | — | 1 | 7.35 |
| CHEMBL515310 | — | — | 1 | 7.35 |
| CHEMBL514992 | — | — | 1 | 7.33 |
| CHEMBL467898 | — | — | 1 | 7.32 |
| CHEMBL511239 | — | — | 1 | 7.28 |
| CHEMBL475973 | — | — | 1 | 7.28 |
| CHEMBL476813 | — | — | 1 | 7.28 |
| CHEMBL476395 | — | — | 1 | 7.27 |
| CHEMBL477016 | — | — | 1 | 7.26 |
| CHEMBL466234 | — | — | 1 | 7.21 |
| CHEMBL476599 | — | — | 1 | 7.21 |
| CHEMBL468945 | — | — | 1 | 7.19 |
| CHEMBL446212 | — | — | 1 | 7.11 |
| CHEMBL500025 | — | — | 1 | 7.09 |
| CHEMBL262628 | — | — | 1 | 7.07 |
| CHEMBL515010 | — | — | 1 | 7.06 |
| CHEMBL476609 | — | — | 1 | 7.03 |
| CHEMBL521690 | — | — | 1 | 6.92 |
| CHEMBL515782 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL501294 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL1092054 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL469126 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL468294 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL468094 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL513854 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL467258 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL513835 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL468946 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL466832 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL475972 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL467897 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL515310 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL514992 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL467898 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL475973 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL476813 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL511239 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL476395 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL477016 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL466234 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL476599 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL468945 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL446212 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL500025 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL262628 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL515010 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL476609 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL521690 | — | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL515782 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 1070.0 | nM | 5.97 |