Assay Detail
Binding
CHEMBL1106396
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Inhibition of human liver fructose-1,6-bisphosphatase expressed in Escherichia coli BL21 (DE3) assessed as reduction of NADP+ to NADPH by phosphoglucose isomerase/glucose-6-phosphate dehydrogenase coupled assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Designing inhibitors against fructose 1,6-bisphosphatase: exploring natural products for novel inhibitor scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.11 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1097227 | — | — | 1 | 5.22 |
| CHEMBL1097226 | — | — | 1 | 5.09 |
| CHEMBL752 | ADENOSINE PHOSPHATE | 4.0 | 1 | 5.01 |
| CHEMBL367881 | (+)-USNIC ACID | — | 1 | - |
| CHEMBL1096898 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1097227 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1097226 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL752 | ADENOSINE PHOSPHATE | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL367881 | (+)-USNIC ACID | IC50 | = | 371000.0 | nM | - |
| CHEMBL1096898 | — | IC50 | - | — | - |