Assay Detail
Functional
CHEMBL1106463
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Cytotoxicity against human WS1 cells after 48 hrs by resazurin reduction assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WS1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro cytotoxic activity of isolated acridones alkaloids from Zanthoxylum leprieurii Guill. et Perr.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.48 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.37 |
| CHEMBL1095073 | TEGERRARDIN A | — | 1 | 4.38 |
| CHEMBL1094824 | — | — | 1 | 4.29 |
| CHEMBL349609 | ARBORININE | — | 1 | 4.25 |
| CHEMBL1094823 | — | — | 1 | 4.13 |
| CHEMBL1095074 | — | — | 1 | - |
| CHEMBL325864 | SCOPARONE | — | 1 | - |
| CHEMBL449317 | HESPERIDIN | 3.0 | 1 | - |
| CHEMBL1099093 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL1095073 | TEGERRARDIN A | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL1094824 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL349609 | ARBORININE | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL1094823 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL1095074 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL325864 | SCOPARONE | IC50 | > | 100000.0 | nM | - |
| CHEMBL449317 | HESPERIDIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL1099093 | — | IC50 | > | 100000.0 | nM | - |