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Assay Detail

CHEMBL1106602

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of CDC25B
ChEMBL ↗
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

M-phase inducer phosphatase 2 (CHEMBL4804) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B.
Chen HJ, Liu Y, Wang LN, Shen Q, Li J, Nan FJ.
Bioorg Med Chem Lett (2010) 20 : 2876 -2879
PubMed 20363629 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 46 6.01 6.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1095726 — — 1 6.92
CHEMBL1097720 — — 1 6.80
CHEMBL1098494 — — 1 6.77
CHEMBL1099219 — — 1 6.64
CHEMBL1097552 — — 1 6.62
CHEMBL1098495 — — 1 6.60
CHEMBL1097794 — — 1 6.51
CHEMBL1094563 — — 1 6.50
CHEMBL1098821 — — 1 6.47
CHEMBL1095107 — — 1 6.40
CHEMBL1098791 — — 1 6.39
CHEMBL1099201 — — 1 6.35
CHEMBL1098792 — — 1 6.31
CHEMBL1095106 — — 1 6.30
CHEMBL1097152 — — 1 6.28
CHEMBL1097486 — — 1 6.27
CHEMBL1095854 — — 1 6.27
CHEMBL1098806 — — 1 6.14
CHEMBL1095552 — — 1 6.02
CHEMBL1095551 — — 1 6.00
CHEMBL1099200 — — 1 5.96
CHEMBL1098533 — — 1 5.94
CHEMBL1095105 — — 1 5.86
CHEMBL1097485 — — 1 5.83
CHEMBL1098807 — — 1 5.68
CHEMBL1099220 — — 1 5.67
CHEMBL1099221 — — 1 5.58
CHEMBL1097793 — — 1 5.54
CHEMBL1097390 — — 1 5.47
CHEMBL1098476 — — 1 5.36

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1095726 — IC50 = 120.0 nM 6.92
CHEMBL1097720 — IC50 = 160.0 nM 6.80
CHEMBL1098494 — IC50 = 170.0 nM 6.77
CHEMBL1099219 — IC50 = 230.0 nM 6.64
CHEMBL1097552 — IC50 = 240.0 nM 6.62
CHEMBL1098495 — IC50 = 250.0 nM 6.60
CHEMBL1097794 — IC50 = 310.0 nM 6.51
CHEMBL1094563 — IC50 = 320.0 nM 6.50
CHEMBL1098821 — IC50 = 340.0 nM 6.47
CHEMBL1095107 — IC50 = 400.0 nM 6.40
CHEMBL1098791 — IC50 = 410.0 nM 6.39
CHEMBL1099201 — IC50 = 450.0 nM 6.35
CHEMBL1098792 — IC50 = 490.0 nM 6.31
CHEMBL1095106 — IC50 = 500.0 nM 6.30
CHEMBL1097152 — IC50 = 520.0 nM 6.28
CHEMBL1097486 — IC50 = 540.0 nM 6.27
CHEMBL1095854 — IC50 = 540.0 nM 6.27
CHEMBL1098806 — IC50 = 730.0 nM 6.14
CHEMBL1095552 — IC50 = 960.0 nM 6.02
CHEMBL1095551 — IC50 = 1010.0 nM 6.00
CHEMBL1099200 — IC50 = 1110.0 nM 5.96
CHEMBL1098533 — IC50 = 1150.0 nM 5.94
CHEMBL1095105 — IC50 = 1390.0 nM 5.86
CHEMBL1097485 — IC50 = 1470.0 nM 5.83
CHEMBL1098807 — IC50 = 2080.0 nM 5.68
CHEMBL1099220 — IC50 = 2130.0 nM 5.67
CHEMBL1099221 — IC50 = 2600.0 nM 5.58
CHEMBL1097793 — IC50 = 2920.0 nM 5.54
CHEMBL1097390 — IC50 = 3360.0 nM 5.47
CHEMBL1098476 — IC50 = 4330.0 nM 5.36
CHEMBL1098845 — IC50 = 5080.0 nM 5.29
CHEMBL1096490 — IC50 = 30000.0 nM 4.52
CHEMBL1096042 — IC50 = 31900.0 nM 4.50
CHEMBL1097048 — IC50 = 37400.0 nM 4.43
CHEMBL1094420 — IC50 - — -
CHEMBL1095334 — IC50 - — -
CHEMBL1098412 — IC50 - — -
CHEMBL1097049 — IC50 - — -
CHEMBL1095662 — IC50 - — -
CHEMBL1097401 — IC50 - — -
CHEMBL1097402 — IC50 - — -
CHEMBL1096405 — IC50 - — -
CHEMBL1094775 — IC50 - — -
CHEMBL1098411 — IC50 - — -
CHEMBL1094754 — IC50 - — -
CHEMBL1094421 — IC50 - — -