Assay Detail
Binding
CHEMBL1106604
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Inhibition of TCPTP
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 2 (CHEMBL3807) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.35 | 5.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1095726 | — | — | 1 | 5.94 |
| CHEMBL1097720 | — | — | 1 | 5.89 |
| CHEMBL1099219 | — | — | 1 | 5.48 |
| CHEMBL1098845 | — | — | 1 | 4.73 |
| CHEMBL1097390 | — | — | 1 | 4.73 |
| CHEMBL1096042 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1095726 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL1097720 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1099219 | — | IC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL1098845 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL1097390 | — | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL1096042 | — | IC50 | - | — | - |