Assay Detail
Binding
CHEMBL1106782
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Inhibition of Mycobacterium tuberculosis PtpA
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Low molecular weight protein-tyrosine phosphatase A (CHEMBL4542) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 43 | 4.64 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1081579 | — | — | 1 | 5.85 |
| CHEMBL1081956 | — | — | 1 | 5.51 |
| CHEMBL1081578 | — | — | 1 | 5.48 |
| CHEMBL1079479 | — | — | 1 | 5.31 |
| CHEMBL1079478 | — | — | 1 | 5.22 |
| CHEMBL1080496 | — | — | 1 | 4.99 |
| CHEMBL1080488 | — | — | 1 | 4.97 |
| CHEMBL1080667 | — | — | 1 | 4.94 |
| CHEMBL1080495 | — | — | 1 | 4.78 |
| CHEMBL1080311 | — | — | 1 | 4.74 |
| CHEMBL1080494 | — | — | 1 | 4.73 |
| CHEMBL1075857 | — | — | 1 | 4.64 |
| CHEMBL1080018 | — | — | 1 | 4.62 |
| CHEMBL1080017 | — | — | 1 | 4.48 |
| CHEMBL1080202 | — | — | 1 | 4.46 |
| CHEMBL1080201 | — | — | 1 | 4.38 |
| CHEMBL1080016 | — | — | 1 | 4.37 |
| CHEMBL1080200 | — | — | 1 | 4.35 |
| CHEMBL1081937 | — | — | 1 | 4.30 |
| CHEMBL1075838 | — | — | 1 | 4.26 |
| CHEMBL1081936 | — | — | 1 | 4.21 |
| CHEMBL1079495 | — | — | 1 | 4.18 |
| CHEMBL1082130 | — | — | 1 | 4.17 |
| CHEMBL1081935 | — | — | 1 | 4.14 |
| CHEMBL1081583 | — | — | 1 | 4.12 |
| CHEMBL1079662 | — | — | 1 | 4.07 |
| CHEMBL1075689 | — | — | 1 | 4.04 |
| CHEMBL1082129 | — | — | 1 | - |
| CHEMBL1081955 | — | — | 1 | - |
| CHEMBL1079845 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1081579 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL1081956 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL1081578 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL1079479 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL1079478 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL1080496 | — | Ki | = | 10300.0 | nM | 4.99 |
| CHEMBL1080488 | — | Ki | = | 10700.0 | nM | 4.97 |
| CHEMBL1080667 | — | Ki | = | 11400.0 | nM | 4.94 |
| CHEMBL1080495 | — | Ki | = | 16800.0 | nM | 4.78 |
| CHEMBL1080311 | — | Ki | = | 18200.0 | nM | 4.74 |
| CHEMBL1080494 | — | Ki | = | 18500.0 | nM | 4.73 |
| CHEMBL1075857 | — | Ki | = | 22700.0 | nM | 4.64 |
| CHEMBL1080018 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL1080017 | — | Ki | = | 33000.0 | nM | 4.48 |
| CHEMBL1080202 | — | Ki | = | 34900.0 | nM | 4.46 |
| CHEMBL1080201 | — | Ki | = | 41800.0 | nM | 4.38 |
| CHEMBL1080016 | — | Ki | = | 43100.0 | nM | 4.37 |
| CHEMBL1080200 | — | Ki | = | 44600.0 | nM | 4.35 |
| CHEMBL1081937 | — | Ki | = | 49700.0 | nM | 4.30 |
| CHEMBL1075838 | — | Ki | = | 54800.0 | nM | 4.26 |
| CHEMBL1081936 | — | Ki | = | 61600.0 | nM | 4.21 |
| CHEMBL1079495 | — | Ki | = | 65500.0 | nM | 4.18 |
| CHEMBL1082130 | — | Ki | = | 68000.0 | nM | 4.17 |
| CHEMBL1081935 | — | Ki | = | 72400.0 | nM | 4.14 |
| CHEMBL1081583 | — | Ki | = | 75400.0 | nM | 4.12 |
| CHEMBL1079662 | — | Ki | = | 84400.0 | nM | 4.07 |
| CHEMBL1075689 | — | Ki | = | 92300.0 | nM | 4.04 |
| CHEMBL1081060 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL151848 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1081748 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1079660 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1079661 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1079663 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1075731 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1079988 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1079989 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1082128 | — | Ki | - | — | - | |
| CHEMBL1081059 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1075905 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1075973 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1079845 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1081955 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1082129 | — | Ki | > | 100000.0 | nM | - |