Assay Detail
Functional
CHEMBL1106929
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Antiproliferative activity against wild type FLT3 expressing human MV411 cells after 72 hrs by WST8 assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Indirubin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.18 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 8.05 |
| CHEMBL1077291 | — | — | 1 | 7.14 |
| CHEMBL126077 | INDIRUBIN-3-MONOXIME | — | 1 | 6.82 |
| CHEMBL511450 | — | — | 1 | 6.66 |
| CHEMBL1097359 | — | — | 1 | 6.58 |
| CHEMBL337300 | — | — | 1 | 6.44 |
| CHEMBL369303 | — | — | 1 | 6.35 |
| CHEMBL111433 | — | — | 1 | 5.81 |
| CHEMBL604263 | — | — | 1 | 5.78 |
| CHEMBL1095374 | — | — | 1 | 5.62 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.47 |
| CHEMBL594192 | — | — | 1 | 5.37 |
| CHEMBL173445 | — | — | 1 | 5.32 |
| CHEMBL367113 | — | — | 1 | 5.16 |
| CHEMBL1095686 | — | — | 1 | - |
| CHEMBL1083839 | — | — | 1 | - |
| CHEMBL1095687 | — | — | 1 | - |
| CHEMBL1086983 | — | — | 1 | - |
| CHEMBL368689 | — | — | 1 | - |
| CHEMBL367345 | — | — | 1 | - |
| CHEMBL174025 | — | — | 1 | - |
| CHEMBL1085921 | — | — | 1 | - |
| CHEMBL1276127 | INDIRUBIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1077291 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL126077 | INDIRUBIN-3-MONOXIME | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL511450 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1097359 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL337300 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL369303 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL111433 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL604263 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL1095374 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL803 | CYTARABINE | IC50 | = | 3360.0 | nM | 5.47 |
| CHEMBL594192 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL173445 | — | IC50 | = | 4790.0 | nM | 5.32 |
| CHEMBL367113 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1095686 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1083839 | — | IC50 | > | 3550.0 | nM | - |
| CHEMBL1095687 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1086983 | — | IC50 | > | 270.0 | nM | - |
| CHEMBL368689 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL367345 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL174025 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1085921 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1276127 | INDIRUBIN | IC50 | > | 10000.0 | nM | - |