Assay Detail
Functional
CHEMBL1106972
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Cytotoxicity against human HepG2 cells after 72 hrs by luminescence assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Podophyllotoxin analogues active versus Trypanosoma brucei.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.64 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.62 |
| CHEMBL1076673 | — | — | 1 | 7.55 |
| CHEMBL1076672 | — | — | 1 | 7.05 |
| CHEMBL1081214 | SUCCINYLPODOPHYLLOTOXIN | — | 1 | 6.77 |
| CHEMBL1076638 | — | — | 1 | 6.70 |
| CHEMBL1076641 | — | — | 1 | 6.66 |
| CHEMBL1076642 | — | — | 1 | 6.57 |
| CHEMBL1076640 | — | — | 1 | 6.50 |
| CHEMBL379989 | RHIZOXIN | — | 1 | 6.40 |
| CHEMBL1076645 | — | — | 1 | 6.36 |
| CHEMBL1076674 | — | — | 1 | 6.30 |
| CHEMBL1076643 | — | — | 1 | 6.27 |
| CHEMBL1076675 | — | — | 1 | 6.15 |
| CHEMBL1076639 | — | — | 1 | 6.00 |
| CHEMBL1076644 | — | — | 1 | - |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1076673 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1076672 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1081214 | SUCCINYLPODOPHYLLOTOXIN | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1076638 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1076641 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1076642 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1076640 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL379989 | RHIZOXIN | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1076645 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL1076674 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1076643 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL1076675 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL1076639 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1076644 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL6 | INDOMETHACIN | IC50 | > | 50000.0 | nM | - |