Assay Detail
Functional
CHEMBL1107009
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Antiinflammatory activity against IFN-gamma-stimulated mouse RAW264.7 cells assessed as nitrite accumulation after 24 hrs by Griess reagent method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-Cyano-3,10-dioxooleana-1,9(11)-dien-28-oic acid anhydride. A novel and highly potent anti-inflammatory and cytoprotective agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.69 | 7.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1093608 | — | — | 1 | 7.83 |
| CHEMBL1093059 | BARDOXOLONE | 2.0 | 1 | 7.55 |
| CHEMBL1093609 | LUPANE ANHYDRIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1093608 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL1093059 | BARDOXOLONE | IC50 | = | 28.3 | nM | 7.55 |
| CHEMBL1093609 | LUPANE ANHYDRIDE | IC50 | > | 10000.0 | nM | - |