Assay Detail
Binding
CHEMBL1107017
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Inhibition of PDE4
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and synthesis of boron-containing PDE4 inhibitors using soft-drug strategy for potential dermatologic anti-inflammatory application.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.65 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1093373 | — | — | 1 | 7.33 |
| CHEMBL1093375 | — | — | 1 | 7.08 |
| CHEMBL1090022 | — | — | 1 | 7.03 |
| CHEMBL1093730 | — | — | 1 | 6.95 |
| CHEMBL1093376 | — | — | 1 | 6.89 |
| CHEMBL1089680 | — | — | 1 | 6.89 |
| CHEMBL1093962 | — | — | 1 | 6.75 |
| CHEMBL1093706 | — | — | 1 | 6.66 |
| CHEMBL1093705 | — | — | 1 | 6.54 |
| CHEMBL484785 | CRISABOROLE | 4.0 | 1 | 6.31 |
| CHEMBL1093707 | — | — | 1 | 6.12 |
| CHEMBL485358 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1093373 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL1093375 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL1090022 | — | IC50 | = | 94.5 | nM | 7.03 |
| CHEMBL1093730 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL1093376 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1089680 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1093962 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1093706 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL1093705 | — | IC50 | = | 287.0 | nM | 6.54 |
| CHEMBL484785 | CRISABOROLE | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL1093707 | — | IC50 | = | 763.0 | nM | 6.12 |
| CHEMBL485358 | — | IC50 | = | 6420.0 | nM | 5.19 |