Compound Detail
CHEMBL1093962
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL1093962 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SOSLTXWXZNBJIP-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
252.0
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4B CHEMBL275 | IC50 | 6.75 | 6.75 | 180.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.75 | 6.75 | 180.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 180.0 | nM | 6.75 | Inhibition of PDE4 | 20188549 |
| 3',5'-cyclic-AMP phosphodiesterase 4B | IC50 | = | 180.0 | nM | 6.75 | Inhibition of human PDE4 catalytic domain expressed in Escherichia coli | 34875836 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20188549 | 10.1016/j.bmcl.2010.02.010 | Unchecked | 1 |
| 34875836 | 10.1021/acs.jmedchem.1c01691 | 3',5'-cyclic-AMP phosphodiesterase 4B | 1 |
Data from ChEMBL 36 via Core Engine