Assay Detail
Binding
CHEMBL5232718
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Inhibition of human PDE4 catalytic domain expressed in Escherichia coli
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4B (CHEMBL275) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting Metalloenzymes by Boron-Containing Metal-Binding Pharmacophores.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.43 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5268572 | — | — | 1 | 10.30 |
| CHEMBL5268265 | — | — | 1 | 9.92 |
| CHEMBL5289939 | — | — | 1 | 9.62 |
| CHEMBL4872870 | — | — | 1 | 9.38 |
| CHEMBL5290174 | — | — | 1 | 9.15 |
| CHEMBL5278590 | — | — | 1 | 7.62 |
| CHEMBL1093373 | — | — | 1 | 7.33 |
| CHEMBL4467344 | — | — | 1 | 7.22 |
| CHEMBL484785 | CRISABOROLE | 4.0 | 1 | 6.96 |
| CHEMBL1093962 | — | — | 1 | 6.75 |
| CHEMBL5281157 | — | — | 1 | - |
| CHEMBL1093374 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5268572 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL5268265 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL5289939 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL4872870 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL5290174 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5278590 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1093373 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4467344 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL484785 | CRISABOROLE | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1093962 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5281157 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL1093374 | — | IC50 | > | 10.0 | nM | - |