Compound Detail
CHEMBL4467344
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Basic Information
| ChEMBL ID | CHEMBL4467344 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UBMGTTRDNUKZMT-UHFFFAOYSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
276.1
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.22
Ki 1 meas. best 7.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4B CHEMBL275 | IC50 | 7.22 | 6.92 | 60.0 | 2 |
| Unchecked CHEMBL612545 | Ki | 7.19 | 7.19 | 65.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4B | IC50 | = | 60.0 | nM | 7.22 | Inhibition of human PDE4 catalytic domain expressed in Escherichia coli | 34875836 |
| Unchecked | Ki | = | 65.0 | nM | 7.19 | Binding affinity to PDE4 (unknown origin) expressed in Escherichia coli using cA... | 37651875 |
| 3',5'-cyclic-AMP phosphodiesterase 4B | IC50 | = | 240.0 | nM | 6.62 | Inhibition of human PDE4B1 expressed in baculovirus infected sf9 cells incubated... | 26908025 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26908025 | 10.1021/acs.jmedchem.5b01813 | 3',5'-cyclic-AMP phosphodiesterase 4B | 1 |
| 34875836 | 10.1021/acs.jmedchem.1c01691 | 3',5'-cyclic-AMP phosphodiesterase 4B | 1 |
| 37651875 | 10.1016/j.ejmech.2023.115761 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine