Compound Detail
CHEMBL5268572
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Basic Information
| ChEMBL ID | CHEMBL5268572 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CECUZGKZZDAYHR-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
346.2
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 10.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4B CHEMBL275 | IC50 | 10.3 | 10.3 | 0.1 | 1 |
| N-formyl peptide receptor 2 CHEMBL4227 | IC50 | 10.3 | 9.96 | 0.1 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4B | IC50 | = | 0.05 | nM | 10.3 | Inhibition of human PDE4 catalytic domain expressed in Escherichia coli | 34875836 |
| N-formyl peptide receptor 2 | IC50 | = | 0.05 | nM | 10.3 | Cytokine Assays: Cytokine inhibitory activity is determined by measuring the eff... | - |
| N-formyl peptide receptor 2 | IC50 | = | 0.12 | nM | 9.92 | Cytokine Assays: Cytokine inhibitory activity is determined by measuring the eff... | - |
| N-formyl peptide receptor 2 | IC50 | = | 0.22 | nM | 9.66 | Cytokine Assays: Cytokine inhibitory activity is determined by measuring the eff... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34875836 | 10.1021/acs.jmedchem.1c01691 | 3',5'-cyclic-AMP phosphodiesterase 4B | 1 |
Data from ChEMBL 36 via Core Engine