Assay Detail

CHEMBL1107043

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ADMET

Cytotoxicity against rat H9c2 cells after 48 hrs by MTT assay

ChEMBL ↗

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Target

H9c2 (CHEMBL614576) ↗

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H9c2 (CHEMBL614576) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target H9c2

CHEMBL614576

Anchored from Assay target.

Protein identity H9c2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	ADMET
Organism	Rattus norvegicus
Cell Type	H9c2
Confidence	1 — Organism
Curated By	Autocuration

Target

H9c2 (CHEMBL614576) ↗

Type	CELL-LINE
Organism	Rattus norvegicus

Publication

A new cytotoxic tambjamine alkaloid from the Azorean nudibranch Tambja ceutae.

Carbone M, Irace C, Costagliola F, Castelluccio F, Villani G, Calado G, Padula V, Cimino G, Lucas Cervera J, Santamaria R, Gavagnin M.
Bioorg Med Chem Lett (2010) 20 : 2668 -2670
PubMed 20227875 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	5.57	5.57

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1092399	TAMBJAMINE K	—	1	5.57
CHEMBL1091177	—	—	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1092399	TAMBJAMINE K	IC50	=	2700.0	nM	5.57
CHEMBL1091177	—	IC50	=	107000.0	nM	-