Assay Detail
Functional
CHEMBL1107110
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human recombinant alpha 3 GlyR expressed in HEK293 cells assessed as inhibition of glycine current influx by whole cell patch clamp assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Ircinialactams: subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.65 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464651 | — | — | 1 | 5.16 |
| CHEMBL1093848 | IRCINIALACTAM C | — | 1 | 4.52 |
| CHEMBL1092618 | — | — | 1 | 4.52 |
| CHEMBL1092619 | IRCINIALACTAM D | — | 1 | 4.52 |
| CHEMBL1093582 | IRCINIALACTAM A | — | 1 | 4.52 |
| CHEMBL464276 | — | — | 1 | - |
| CHEMBL1093581 | — | — | 1 | - |
| CHEMBL1093847 | 8-HYDROXYIRCINIALACTAM B | — | 1 | - |
| CHEMBL1093838 | 8-HYDROXYIRCINIALACTAM A | — | 1 | - |
| CHEMBL1093564 | — | — | 1 | - |
| CHEMBL1089325 | COMETIN A | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464651 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1093848 | IRCINIALACTAM C | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1092618 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1092619 | IRCINIALACTAM D | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1093582 | IRCINIALACTAM A | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL464276 | — | IC50 | - | — | - | |
| CHEMBL1093581 | — | IC50 | - | — | - | |
| CHEMBL1093847 | 8-HYDROXYIRCINIALACTAM B | IC50 | - | — | - | |
| CHEMBL1093838 | 8-HYDROXYIRCINIALACTAM A | IC50 | - | — | - | |
| CHEMBL1093564 | — | IC50 | - | — | - | |
| CHEMBL1089325 | COMETIN A | IC50 | - | — | - |