Assay Detail
Binding
CHEMBL1107232
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Inhibition of amino acid transport system xc-
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Conformationally-restricted amino acid analogues bearing a distal sulfonic acid show selective inhibition of system x(c)(-) over the vesicular glutamate transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.91 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279956 | QUISQUALATE | — | 1 | 5.30 |
| CHEMBL94990 | — | — | 1 | 5.30 |
| CHEMBL28885 | — | — | 1 | 4.58 |
| CHEMBL230951 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279956 | QUISQUALATE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL94990 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL28885 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL230951 | — | IC50 | = | 35000.0 | nM | 4.46 |