Assay Detail
Functional
CHEMBL1107399
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Agonist activity at human GPR17 R255I mutant expressed in human 1321N1 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by rapid filtration assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1321-N1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Frontal affinity chromatography-mass spectrometry useful for characterization of new ligands for GPR17 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.28 | 10.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1097652 | — | — | 1 | 10.60 |
| CHEMBL1094759 | — | — | 1 | 5.73 |
| CHEMBL1096401 | UDP TRISODIUM | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1097652 | — | EC50 | = | 0.0254 | nM | 10.60 |
| CHEMBL1094759 | — | EC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL1096401 | UDP TRISODIUM | EC50 | = | 3000.0 | nM | 5.52 |