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Assay Detail

CHEMBL1107472

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of LTB4-stimulated human neutrophils migration after 30 mins by using CyQuant GR fluorescent dye
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Neutrophil
Confidence 1 — Organism
Curated By Autocuration

Target

Neutrophil (CHEMBL613710)
Type CELL-LINE

Publication

Discovery of novel and potent leukotriene B4 receptor antagonists. Part 1.
Goodnow RA, Hicks A, Sidduri A, Kowalczyk A, Dominique R, Qiao Q, Lou JP, Gillespie P, Fotouhi N, Tilley J, Cohen N, Choudhry S, Cavallo G, Tannu SA, Ventre JD, Lavelle D, Tare NS, Oh H, Lamb M, Kurylko G, Hamid R, Wright MB, Pamidimukkala A, Egan T, Gubler U, Hoffman AF, Wei X, Li YL, O'Neil J, Marcano R, Pozzani K, Molinaro T, Santiago J, Singer L, Hargaden M, Moore D, Catala AR, Chao LC, Hermann G, Venkat R, Mancebo H, Renzetti LM.
J Med Chem (2010) 53 : 3502 -3516
PubMed 20380377 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 9.12 10.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1098560 1 10.00
CHEMBL1094346 1 10.00
CHEMBL1099331 1 9.70
CHEMBL1099335 1 9.70
CHEMBL1094347 1 9.70
CHEMBL1099337 1 9.15
CHEMBL1099330 1 8.74
CHEMBL1094348 1 8.43
CHEMBL1094349 1 8.12
CHEMBL1099334 1 7.70
CHEMBL1099332 1 -
CHEMBL1099333 1 -
CHEMBL1099336 1 -
CHEMBL1099338 1 -
CHEMBL1094350 1 -
CHEMBL15766 LY-255283 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1098560 IC50 = 0.1 nM 10.00
CHEMBL1094346 IC50 = 0.1 nM 10.00
CHEMBL1099331 IC50 = 0.2 nM 9.70
CHEMBL1099335 IC50 = 0.2 nM 9.70
CHEMBL1094347 IC50 = 0.2 nM 9.70
CHEMBL1099337 IC50 = 0.7 nM 9.15
CHEMBL1099330 IC50 = 1.8 nM 8.74
CHEMBL1094348 IC50 = 3.68 nM 8.43
CHEMBL1094349 IC50 = 7.67 nM 8.12
CHEMBL1099334 IC50 = 20.0 nM 7.70
CHEMBL1099332 IC50 - -
CHEMBL1099333 IC50 - -
CHEMBL1099336 IC50 - -
CHEMBL1099338 IC50 - -
CHEMBL1094350 IC50 - -
CHEMBL15766 LY-255283 IC50 - -