Assay Detail
Functional
CHEMBL1107473
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Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel and potent leukotriene B4 receptor antagonists. Part 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.02 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1099323 | — | — | 1 | 7.42 |
| CHEMBL1099326 | — | — | 1 | 7.15 |
| CHEMBL1098560 | — | — | 1 | 6.94 |
| CHEMBL1094348 | — | — | 1 | 6.89 |
| CHEMBL1099330 | — | — | 1 | 6.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1099323 | — | IC50 | = | 38.5 | nM | 7.42 |
| CHEMBL1099326 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL1098560 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL1094348 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL1099330 | — | IC50 | = | 205.0 | nM | 6.69 |