Assay Detail
Binding
CHEMBL1107564
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Inhibition of bovine milk XOR-mediated uric acid formation after 15 mins by spectrophotometer
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 3-(2-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051 - a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia [corrected].
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 7.43 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1079332 | — | — | 1 | 8.48 |
| CHEMBL468704 | — | — | 1 | 8.43 |
| CHEMBL1079334 | — | — | 1 | 8.33 |
| CHEMBL1077405 | — | — | 1 | 8.31 |
| CHEMBL1078685 | TOPIROXOSTAT | 2.0 | 1 | 8.28 |
| CHEMBL1078763 | — | — | 1 | 8.17 |
| CHEMBL1077446 | — | — | 1 | 8.10 |
| CHEMBL1078761 | — | — | 1 | 8.00 |
| CHEMBL1082212 | — | — | 1 | 7.77 |
| CHEMBL1078560 | — | — | 1 | 7.75 |
| CHEMBL1077386 | — | — | 1 | 7.62 |
| CHEMBL1078980 | — | — | 1 | 7.55 |
| CHEMBL1079331 | — | — | 1 | 7.52 |
| CHEMBL460158 | — | — | 1 | 7.51 |
| CHEMBL1079084 | — | — | 1 | 7.42 |
| CHEMBL1078559 | — | — | 1 | 7.41 |
| CHEMBL1080059 | — | — | 1 | 7.34 |
| CHEMBL1078762 | — | — | 1 | 7.32 |
| CHEMBL1080767 | — | — | 1 | 7.23 |
| CHEMBL1080057 | — | — | 1 | 7.23 |
| CHEMBL1080058 | — | — | 1 | 7.20 |
| CHEMBL1081134 | — | — | 1 | 7.05 |
| CHEMBL1077387 | — | — | 1 | 6.89 |
| CHEMBL1079103 | — | — | 1 | 6.77 |
| CHEMBL1078978 | — | — | 1 | 6.77 |
| CHEMBL1080056 | — | — | 1 | 6.77 |
| CHEMBL1079001 | — | — | 1 | 6.51 |
| CHEMBL1079104 | — | — | 1 | 6.23 |
| CHEMBL1467 | ALLOPURINOL | 4.0 | 1 | 5.64 |
| CHEMBL1078308 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1079332 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL468704 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL1079334 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL1077405 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL1078685 | TOPIROXOSTAT | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL1078763 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL1077446 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL1078761 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL1082212 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1078560 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1077386 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1078980 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1079331 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL460158 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1079084 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1078559 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1080059 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL1078762 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL1080767 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL1080057 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL1080058 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL1081134 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL1077387 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1079103 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1078978 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1080056 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1079001 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1079104 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1467 | ALLOPURINOL | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1078308 | — | IC50 | - | — | - | |
| CHEMBL1078310 | — | IC50 | - | — | - | |
| CHEMBL1080060 | — | IC50 | - | — | - | |
| CHEMBL1078309 | — | IC50 | - | — | - | |
| CHEMBL468706 | — | IC50 | = | 17.0 | nM | - |
| CHEMBL460160 | — | IC50 | = | 10.0 | nM | - |
| CHEMBL1078311 | — | IC50 | - | — | - |