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Target Snapshot

CHEMBL3649 Target Snapshot

Xanthine dehydrogenase/oxidase · SINGLE PROTEIN · Bos taurus

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1,721Compounds
248Assays
5Approved Drugs
1,523.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P80457. Use UniProt P80457 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P80457 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Xanthine dehydrogenase/oxidase as ChEMBL target CHEMBL3649, mapped to UniProt P80457. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Xanthine dehydrogenase/oxidase
SINGLE PROTEIN · Bos taurus
As of 2026-09-13
ChEMBL target ID
CHEMBL3649
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P80457
Xanthine dehydrogenase/oxidase
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Xanthine dehydrogenase/oxidase is the right protein anchor across sources, using UniProt P80457 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameXanthine dehydrogenase/oxidase
Target TypeSINGLE PROTEIN
OrganismBos taurus
UniProtP80457
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelXanthine dehydrogenase/oxidase
UniProt AccessionP80457
Component TypeProtein
Sequence Length1332 aa

Xanthine dehydrogenase/oxidase

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Xanthine dehydrogenase/oxidase, mapped to UniProt P80457. Sequence length is 1332 aa.

Mapped IDP80457
Review nameXanthine dehydrogenase/oxidase
OrganismBos taurus
Clinical Profile

Clinical Phase Distribution

5
Approved
3
Phase III
6
Phase II
Assay Mix

Activity Type Distribution

IC501,429.0
KI63.0
EC5030.0
KD1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1164729 9.92 Ki 0.12 Approved
CHEMBL1467 9.27 Kd 0.54 Approved
CHEMBL3331617 9.05 Ki 0.9 Preclinical
CHEMBL5426192 8.89 IC50 1.3 Preclinical
CHEMBL5408075 8.88 IC50 1.32 Preclinical
CHEMBL5395447 8.87 IC50 1.35 Preclinical
CHEMBL5405574 8.85 IC50 1.4 Preclinical
CHEMBL5408526 8.8 IC50 1.58 Preclinical
CHEMBL5436044 8.78 IC50 1.67 Preclinical
CHEMBL3667863 8.77 IC50 1.7 Preclinical
Distribution

pChEMBL Value Distribution

143
5.0
123
5.5
69
6.0
75
6.5
182
7.0
191
7.5
214
8.0
37
8.5
4
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

FEBUXOSTAT
CHEMBL1164729
Approved 2008
Properties Compare Identifier
ALLOPURINOL
CHEMBL1467
Approved 1966
Properties Compare Identifier
Assay Landscape

Assay Landscape

248
Total Assays
1,206
Tested Compounds
1
Assay Types
Binding — 248 assays, 1,206 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 246 1,203 6.5
cell-free format 1 1 6.4
tissue-based format 1 2 5.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine