Assay Detail
Binding
CHEMBL1107755
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Inhibition of GST-tagged JAK3 kinase
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.46 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 8.30 |
| CHEMBL1078364 | — | — | 1 | 8.05 |
| CHEMBL1078274 | — | — | 1 | 7.21 |
| CHEMBL1078166 | — | — | 1 | 7.18 |
| CHEMBL1078005 | — | — | 1 | 7.07 |
| CHEMBL1078275 | — | — | 1 | 6.96 |
| CHEMBL1079078 | — | — | 1 | 6.83 |
| CHEMBL1078933 | — | — | 1 | 6.82 |
| CHEMBL1078178 | MOMELOTINIB | 4.0 | 1 | 6.81 |
| CHEMBL1078934 | — | — | 1 | 6.72 |
| CHEMBL1078228 | — | — | 1 | 6.56 |
| CHEMBL1079077 | — | — | 1 | 6.46 |
| CHEMBL1077842 | — | — | 1 | 6.44 |
| CHEMBL1077841 | — | — | 1 | 6.44 |
| CHEMBL1078720 | — | — | 1 | 6.44 |
| CHEMBL1078276 | — | — | 1 | 6.27 |
| CHEMBL1078889 | — | — | 1 | 6.23 |
| CHEMBL1078688 | — | — | 1 | 6.20 |
| CHEMBL1078277 | — | — | 1 | 6.03 |
| CHEMBL1078866 | — | — | 1 | 6.02 |
| CHEMBL1078370 | — | — | 1 | 5.85 |
| CHEMBL1078721 | — | — | 1 | 5.84 |
| CHEMBL1078767 | — | — | 1 | 5.79 |
| CHEMBL1077575 | — | — | 1 | 5.75 |
| CHEMBL1078229 | — | — | 1 | 5.73 |
| CHEMBL1079121 | — | — | 1 | 5.70 |
| CHEMBL1079120 | — | — | 1 | 5.64 |
| CHEMBL1078453 | — | — | 1 | 5.41 |
| CHEMBL1078363 | — | — | 1 | - |
| CHEMBL1078689 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL221959 | TOFACITINIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1078364 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1078274 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL1078166 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL1078005 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL1078275 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1079078 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL1078933 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL1078178 | MOMELOTINIB | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL1078934 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL1078228 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL1079077 | — | IC50 | = | 351.0 | nM | 6.46 |
| CHEMBL1077842 | — | IC50 | = | 364.0 | nM | 6.44 |
| CHEMBL1077841 | — | IC50 | = | 364.0 | nM | 6.44 |
| CHEMBL1078720 | — | IC50 | = | 362.0 | nM | 6.44 |
| CHEMBL1078276 | — | IC50 | = | 538.0 | nM | 6.27 |
| CHEMBL1078889 | — | IC50 | = | 587.0 | nM | 6.23 |
| CHEMBL1078688 | — | IC50 | = | 636.0 | nM | 6.20 |
| CHEMBL1078277 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL1078866 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL1078370 | — | IC50 | = | 1418.0 | nM | 5.85 |
| CHEMBL1078721 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL1078767 | — | IC50 | = | 1619.0 | nM | 5.79 |
| CHEMBL1077575 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL1078229 | — | IC50 | = | 1876.0 | nM | 5.73 |
| CHEMBL1079121 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL1079120 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL1078453 | — | IC50 | = | 3910.0 | nM | 5.41 |
| CHEMBL1078363 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1078689 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1078165 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1078159 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1078971 | — | IC50 | > | 1000.0 | nM | - |